PRP Research

Platelet-rich plasma as a treatment for Plantar Fasciitis: A meta-analysis of randomized controlled trials

Recent studies have shown that PRP can increase collagen gene expression and production of vascular endothelial growth factor to promote tendon healing.[37] High concentrations of PRP can be effective in recruiting regenerative cells and increasing angiogenesis.[38] The presence of growth factors in the PRP allows the regenerative process to begin shortly after administration. This process may require a minimum time period to achieve its maximum clinical efficacy, which may explain the equivalent short-term effects of PRP and steroids and the improved long-term effects of PRP. Because the steroid group did not display differences in the FADI (WMD = 14.08, 95% CI: −11.57 to 39.73, P = .28, I2 = 99%), AOFAS (WMD = 0.94, 95% CI: −5.99 to 7.86, P = .79, I2 = 81%), or RMS (RR = 1.75, 95% CI: 0.27–11.38, P = .56, I2 = 90%), we concluded that PRP and steroids have similar effects on functional improvement.

Conclusions: PRP is as effective as Steroid injection at achieving symptom relief at 3 and 6 months after injection, for the treatment of plantar fasciitis, but unlike Steroid, its effect does not wear off with time. At 12 months, PRP is significantly more effective than Steroid, making it better and more durable than cortisone injection.

Platelet rich plasma versus corticosteroid injection for plantar fasciitis: A comparative study | Request PDF. Available from:

https://www.researchgate.net/publication/281713392_Platelet_rich_plasma_versus_corticosteroid_injection_for_plantar_fasciitis_A_comparative_study

Chronic Plantar Fasciitis: Effect of Platelet-Rich Plasma, Corticosteroid, and Placebo.

The authors concluded that local injection of platelet-rich plasma or corticosteroid is an effective treatment option for chronic plantar fasciitis. Platelet-rich plasma injection is as effective as or more effective than corticosteroid injection in treating chronic plantar fasciitis.

Autologous platelet-rich plasma versus dextrose prolotherapy for the treatment of chronic recalcitrant plantar fasciitis

21 patients diagnosed with chronic recalcitrant plantar fasciitis were randomized to receive either dextrose prolotherapy (DP) or autologous platelet-rich plasma (PRP) injection therapy. The purpose was to evaluate the efficacies of these treatments and additionally, to assess whether one is more effective. Results at 28 weeks indicated that both treatments significantly improved total Foot Function Index scores versus baseline but no between-group differences were found. Nevertheless, PRP provided greater overall improvements from baseline in short-term functional subscales and outcome compared to DP.

Platelet rich plasma superior to corticosteroid injections for plantar fasciitis treatment

40 patients with chronic unilateral plantar fasciitis, who had failed extensive, traditional, nonoperative management, were randomly assigned into 1 of 2 treatment groups to determine if platelet rich plasma injections effectively treated chronic unilateral plantar fasciitis. Patients either received a single ultrasound guided injection of autologous platelet-rich plasma or a 40 mg injection of DepoMedrol cortisone. The results of the study indicated that patients in the platelet rich plasma group experienced significantly greater increases in mean AOFAS score at all follow up months, when compared to the cortisone injection group, and maintained this improvement by the final 24 month follow up.

PRGF/PDGF Research

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